tagD [2019-08-12 09:08:52]

glycerol-3-phosphate cytidylyltransferase

Locus: BSU_35740

Isoelectric point: 5.67

Molecular weight: 15.13 kDa

Protein length: 129 aa

Gene length: 390 bp

Function: biosynthesis of teichoic acid

Product: glycerol-3-phosphate cytidylyltransferase

Essential: yes

E.C.: 2.7.7.39

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
• Groups of genes → Essential genes

Gene

Coordinates: 3,680,581 3,680,970

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol (according to Swiss-Prot)

Protein family

• cytidylyltransferase family (with IspD and YfnH, according to UniProt)

Structure

• 1N1D (complex with CDP-glycerol) PubMed, 1COZ

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: tagD-tagE-tagF-tagG-tagH
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • PhoP: repression, PubMed, in PhoP regulon
  • WalR: activation, PubMed, in WalR regulon

  Regulation

  • repressed by phosphate (PhoP) PubMed

References

Reviews

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Original publications

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